Dermelloa

Squalane

Evidence types available

Human clinical trialIn vitro

A hydrogenated and stabilised form of squalene — a lipid naturally produced by human sebaceous glands that declines measurably with age. Squalane (not squalene) is stable for use in cosmetics and functions as a lightweight, non-greasy emollient that replenishes skin lipids and reduces transepidermal water loss without occluding pores. Human skin recognises it as a native lipid, making it exceptionally well-tolerated and non-comedogenic across most skin types. Sourced from olives, sugarcane, or sharks (the latter now largely discontinued). Human clinical evidence for barrier repair and skin softening is solid; typically used at 1–100% depending on the formulation. One of the most broadly compatible oils in skincare.

How squalane works in skin

Mimics skin's own sebum

Identical structure to natural squalene

Occlusive barrier seal

Prevents moisture escaping the surface

Full cited breakdown coming soon. In the meantime the summary above reflects the current research.