Dermelloa

Polyglutamic Acid

Evidence types available

Human clinical trialIn vitro

A naturally occurring biopolymer produced by Bacillus subtilis fermentation that can hold 4–5 times more water than hyaluronic acid by weight. Unlike most molecular weights of hyaluronic acid, it primarily forms a film on the skin surface, preventing moisture evaporation rather than penetrating to deliver hydration from within. This film-forming property also helps retain hyaluronic acid at the skin surface, making it a useful combination ingredient. Human clinical evidence is growing but thinner than the hyaluronic acid literature. Well-tolerated and suitable for all skin types. Most effective used alongside humectants rather than as a standalone hydration strategy.

How polyglutamic acid works in skin

Larger molecule than hyaluronic acid

Stays on the surface — strong film-forming effect

Reduces water loss

Occlusive humectant layer on stratum corneum

Full cited breakdown coming soon. In the meantime the summary above reflects the current research.