Dermelloa

Panthenol (Vitamin B5)

Evidence types available

Human clinical trialIn vitro

A provitamin of pantothenic acid (B5) that penetrates the skin and converts to pantothenic acid, where it supports cellular metabolism, wound healing, and barrier repair. One of the most well-tolerated skincare ingredients across all skin types, including reactive and compromised skin. Acts as a humectant, drawing moisture to the skin surface; also has demonstrated anti-inflammatory and wound-healing properties in human studies. Commonly used at 1–5% in moisturisers and barrier creams. A genuinely multi-functional ingredient with a strong tolerability profile — one of the few actives that is almost universally well-received.

How panthenol (B5) works in skin

Converts to pantothenic acid

Supports barrier lipid synthesis

Humectant — draws in water

Holds moisture in the epidermis

Accelerates wound healing

Promotes keratinocyte proliferation

Full cited breakdown coming soon. In the meantime the summary above reflects the current research.