Dermelloa

Mandelic Acid

Evidence types available

Human clinical trial

An alpha-hydroxy acid (AHA) derived from bitter almonds with a larger molecular structure than glycolic acid, resulting in slower and more superficial penetration. This makes it better tolerated on sensitive or reactive skin and significantly less likely to cause post-inflammatory hyperpigmentation — making it the preferred AHA for medium-to-deep skin tones where glycolic acid can trigger PIH rather than fade it. Evidence base is thinner than glycolic acid (fewer large RCTs), but clinical results for mild photoaging, acne, and uneven tone are well-documented in practice and smaller studies.

How mandelic acid works in skin

Largest common AHA molecule

Slowest penetration — gentlest exfoliant

Fades pigmentation

Inhibits tyrosinase, accelerates cell turnover

Full cited breakdown coming soon. In the meantime the summary above reflects the current research.