Dermelloa

Centella Asiatica

Evidence types available

Human clinical trialIn vitro

An herbaceous plant used in traditional Ayurvedic and TCM medicine that has accumulated a meaningful modern evidence base. Active compounds — asiaticoside, asiatic acid, madecassic acid, and madecassoside — stimulate fibroblast proliferation and collagen synthesis, and accelerate wound healing. Human RCT evidence for hypertrophic scar treatment and skin repair is solid. Anti-inflammatory effects are also documented in human studies. One of the few traditional botanical ingredients in skincare where the mechanism is understood at a cellular level and where RCT data at clinically relevant concentrations exists.

How centella asiatica works in skin

Madecassoside calms inflammation

Reduces redness and sensitisation

↑ Collagen via TGF-β pathway

Asiaticoside stimulates wound repair

Full cited breakdown coming soon. In the meantime the summary above reflects the current research.